FinnGen 3 Neurodegenerative Disease Task Force access request
10.04.2025
FinnGen is a 10-year study aiming to identify genetic risk factors for thousands of diseases. The third phase of the FinnGen study focuses on deeper analyses of diseases and genetic variants identified in the earlier phases without expanding the current cohort of 520,000 participants. The project will emphasize longitudinal studies of disease progression and therapeutic responses and explore the biological mechanisms of genetic signals in selected diseases. New health data and molecular profiling data will be integrated with the existing data to further boost our understanding of the biological processes underlying disease development in individuals with specific genetic variants. The aim is to study the progression of Alzheimer’s disease by analyzing existing brain MRI scans alongside novel, highly sensitive plasma biomarkers. Combining imaging data with genetic and biomarker information could improve the accuracy of staging the disease and predicting its course. In the future,this knowledge could be applied to identify high-risk individuals, supporting clinical diagnostics and prognostic evaluations.
